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Primate Biology An international open-access journal on primate research
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PB | Articles | Volume 6, issue 2
Primate Biol., 6, 75–86, 2019
https://doi.org/10.5194/pb-6-75-2019
© Author(s) 2019. This work is distributed under
the Creative Commons Attribution 4.0 License.
Primate Biol., 6, 75–86, 2019
https://doi.org/10.5194/pb-6-75-2019
© Author(s) 2019. This work is distributed under
the Creative Commons Attribution 4.0 License.

Research article 29 Jul 2019

Research article | 29 Jul 2019

Baboon induced pluripotent stem cell generation by piggyBac transposition of reprogramming factors

Ignacio Rodriguez-Polo et al.
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Cited articles  
Aeckerle, N., Drummer, C., Debowski, K., Viebahn, C., and Behr, R.: Primordial germ cell development in the marmoset monkey as revealed by pluripotency factor expression: suggestion of a novel model of embryonic germ cell translocation, Mol. Hum. Reprod., 21, 552–552, https://doi.org/10.1093/molehr/gav016, 2015. 
Agrba, V. Z., Porkhanov, V. A., Karal-Ogly, D. D., Leontyuk, A. V, Kovalenko, A. L., Sholin, I. Y., Gvozdik, T. E., Ignatova, I. E., Agumava, A. A., Chuguev, Y. P., Gvaramiya, I. A., and Lapin, B. A.: Transplantation of Simian Mesenchymal Stem Cells to Baboons with Experimentally Induced Myocardial Infarction, B. Exp. Biol. Med., 160, 589–591, https://doi.org/10.1007/s10517-016-3223-7, 2016. 
Bailey, L.: The Baboon in Biomedical Research – The Baboon in Xenotransplant Research, Springer, edited by: Williams-Blangero, S., Tardif, S. D., and VandeBerg, J. L., Springer, New York, NY, 2009. 
Behr, R.: Primate biologics research at a crossroads, Potential of Genetically Modified Nonhuman Primate Models for Biomedicine, edited by: Weinbauer, G. F. and Vogel, F., Waxmann, Münster, New York, 2015. 
Carcamo-Orive, I., Hoffman, G. E., Cundiff, P., Beckmann, N. D., D'Souza, S. L., Knowles, J. W., Patel, A., Papatsenko, D., Abbasi, F., Reaven, G. M., Whalen, S., Lee, P., Shahbazi, M., Henrion, M. Y. R., Zhu, K., Wang, S., Roussos, P., Schadt, E. E., Pandey, G., Chang, R., Quertermous, T., and Lemischka, I.: Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity, Cell Stem Cell, 20, 1–15, https://doi.org/10.1016/j.stem.2016.11.005, 2017. 
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Stem-cell-based regenerative therapies in patients, e.g., for a failing heart or Parkinson's disease, are within reach. However, studies in appropriate animal models are required to make the final step to the clinic. In this context, the baboon may represent a valuable animal model for specific purposes. Here, we generated five so-called induced pluripotent stem cell lines from the baboon, which may be useful for preclinical testing of the respective therapeutic approaches.
Stem-cell-based regenerative therapies in patients, e.g., for a failing heart or Parkinson's...
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