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Primate Biology An international open-access journal on primate research
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Volume 4, issue 2
Primate Biol., 4, 185-213, 2017
https://doi.org/10.5194/pb-4-185-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 4.0 License.

Special issue: Stem cells in non-human primates

Primate Biol., 4, 185-213, 2017
https://doi.org/10.5194/pb-4-185-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 4.0 License.

Review article 11 Oct 2017

Review article | 11 Oct 2017

Transplantation in the nonhuman primate MPTP model of Parkinson's disease: update and perspectives

Florence Wianny1 and Julien Vezoli2 Florence Wianny and Julien Vezoli
  • 1Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France
  • 2Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany

Abstract. In order to calibrate stem cell exploitation for cellular therapy in neurodegenerative diseases, fundamental and preclinical research in NHP (nonhuman primate) models is crucial. Indeed, it is consensually recognized that it is not possible to directly extrapolate results obtained in rodent models to human patients. A large diversity of neurological pathologies should benefit from cellular therapy based on neural differentiation of stem cells. In the context of this special issue of Primate Biology on NHP stem cells, we describe past and recent advances on cell replacement in the NHP model of Parkinson's disease (PD). From the different grafting procedures to the various cell types transplanted, we review here diverse approaches for cell-replacement therapy and their related therapeutic potential on behavior and function in the NHP model of PD.

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We propose for this special issue an exhaustive review of past and most recent advances on the topic of cell replacement in Parkinson’s disease, describing the different procedures using transplantation of various cell sources as a therapeutic approach and linked therapeutic behavioral and/or functional outcomes. We conclude by opening perspectives on future promising developments for the use of cell-replacement therapy in research and its translation to the clinic.
We propose for this special issue an exhaustive review of past and most recent advances on the...
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