Journal cover Journal topic
Primate Biology An international open-access journal on primate research
Primate Biol., 4, 131-142, 2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
Review article
30 Jun 2017
Use of nonhuman primates in obstructive lung disease research – is it required?
Franziska Dahlmann1,2 and Katherina Sewald2 1German Primate Center GmbH, Infection Pathology Unit, Kellnerweg 4, 37077 Göttingen, Germany
2Fraunhofer Institute for Toxicology and Experimental Medicine, Preclinical Pharmacology and Immunology, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Nikolai-Fuchs-Straße 1, 30625 Hanover, Germany
Abstract. In times of increasing costs for health insurances, obstructive lung diseases are a burden for both the patients and the economy. Pulmonary symptoms of asthma and chronic obstructive pulmonary disease (COPD) are similar; nevertheless, the diseases differ in pathophysiology and therapeutic approaches. Novel therapeutics are continuously developed, and nonhuman primates (NHPs) provide valuable models for investigating novel biologicals regarding efficacy and safety.

This review discusses the role of nonhuman primate models for drug development in asthma and COPD and investigates whether alternative methods are able to prevent animal experiments.

Citation: Dahlmann, F. and Sewald, K.: Use of nonhuman primates in obstructive lung disease research – is it required?, Primate Biol., 4, 131-142,, 2017.
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